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You can, but its important to go in with realistic expectations

Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J (2004) Beyond insulin resistance in NASH: tNF-alpha or adiponectin

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It is common in clinical practice to draw a high-viscosity solution with a lower-gauge needle (e.g., 18G - 20G) and then switch to a higher-gauge needle (e.g., 23G - 25G) for the administration

Toxic A oligomers activate microglia and encourage the release of pro-inflammatory cytokines (De Felice et al., 2022)